Certificate of Analysis
| Product Name: | Vemurafenib (PLX4032) |
| Catalog Number: | M1761 |
| CAS Number: | 918504-65-1 |
Physical and Chemical Properties
| Formula: | C23H18ClF2N3O3S |
| Molecular Weight: | 489.92 |
| Solubility: | DMSO 60 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.34% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Vemurafenib (PLX4032) is a first-in-class, potent, selective inhibitor of B-Raf that inhibits RAFV600E and C-RAF-1 activity with IC50s of 31 nM and 48 nM, respectively.In addition, Vemurafenib induces autophagy. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |