Certificate of Analysis


Product Name: (+)-JQ1
Catalog Number: M2167
CAS Number: 1268524-70-4

Physical and Chemical Properties
Formula: C23H25ClN4O2S
Molecular Weight: 456.99
Solubility: DMSO 45 mg/mL; Ethanol 45 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: (+)-JQ1 Structure
Analytical Data
QC Standard: 98.80%
H-NMR: Consistent with structure
Product Information
Description: (+)-JQ1 is a BET bromodomain inhibitor that acts on BRD4(2) with an IC50 of 33 nM and binds to all bromodomain domains in the BET family, but not to bromodomain domains outside the BET family. JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway, and JQ1 down-regulates CD47 expression through a C-MYC-mediated pathway.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.