Certificate of Analysis
| Product Name: | Pladienolide B |
| Catalog Number: | M7145 |
| CAS Number: | 445493-23-2 |
Physical and Chemical Properties
| Formula: | C30H48O8 |
| Molecular Weight: | 536.7 |
| Solubility: | DMSO |
| Storage: | -20°C, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Pladienolide B is a potent pre-mRNA splicing inhibitor, exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. Pladienolide B induces apoptosis. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |