Certificate of Analysis
| Product Name: | Pirtobrutinib (LOXO-305) |
| Catalog Number: | M10604 |
| CAS Number: | 2101700-15-4 |
Physical and Chemical Properties
| Formula: | C22H21F4N5O3 |
| Molecular Weight: | 479.43 |
| Solubility: | DMSO 60 mg/mL |
| Storage: | 2-8°C, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.94% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Pirtobrutinib (LOXO-305; LY 3527727; RXC-005) is a first-in-class, highly selective, non-covalent, next-generation BTK inhibitor with an IC50 of 5.69 nM in WT BTK HEK cells.Pirtobrutinib's selectivity for BTK more than 300 times more selective than other 370 kinases. Pirtobrutinib can be used in studies related to chronic lymphocytic leukemia (CLL). |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |