Certificate of Analysis
| Product Name: | Crizotinib (PF-02341066) |
| Catalog Number: | M1765 |
| CAS Number: | 877399-52-5 |
Physical and Chemical Properties
| Formula: | C21H22Cl2FN5O |
| Molecular Weight: | 450.34 |
| Solubility: | DMSO 11 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.89% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Crizotinib (PF-02341066) is a potent, orally bioavailable, ATP-competitive small-molecule inhibitor of c-Met kinase and ALK (anaplastic lymphoma kinase) with IC50 values to be 4 and 25 nM for C-Met and ALK resepectively. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |