Certificate of Analysis


Catalog Number: M1806
Product Name: PD 0332991 HCL
CAS Number: 827022-32-2

Physical and Chemical Properties
Formula: C24H29N7O2.HCl
Molecular Weight: 483.99
Solubility: DMSO 4 mg/mL warmed, Water 30 mg/mL
Storage: at -20°C
Chemical Structure: PD 0332991 HCL Structure
Analytical Data
HPLC: Shows Min 99.90% purity
H-NMR: Consistent with structure
Product Information
Description: PD-0332991 HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.