Product Name: | Onametostat (JNJ-64619178) |
Catalog Number: | M13371 |
CAS Number: | 2086772-26-9 |
Formula: | C22H23BrN6O2 |
Molecular Weight: | 483.36 |
Solubility: | DMSO ≥ 60 mg/mL |
Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Chemical Structure: |
QC Standard: | >99% |
H-NMR: | Consistent with structure |
Description: | Onametostat (JNJ-64619178) is a highly selective, orally active, pseudo-irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor (PRMT5-MEP-50, IC50=0.14 nM).Onametostat does not covalently bind to PRMT5, but has a long interaction time. It has good pharmacokinetic properties as well as safety profile. |
Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |