Certificate of Analysis
| Product Name: | NVP-HSP990 |
| Catalog Number: | M1798 |
| CAS Number: | 934343-74-5 |
Physical and Chemical Properties
| Formula: | C20H18FN5O2 |
| Molecular Weight: | 379.39 |
| Solubility: | DMSO 33 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99.5% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | NVP-HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively. NVP-HSP990 has potential antineoplastic activity. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |