Certificate of Analysis
| Product Name: | NSC-87877 disodium salt |
| Catalog Number: | M20614 |
| CAS Number: | 56932-43-5 |
Physical and Chemical Properties
| Formula: | C19H11N3Na2O7S2 |
| Molecular Weight: | 503.42 |
| Solubility: | DMSO 100 mg/mL; Water 100 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | NSC-87877 disodium is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. NSC-87877 disodium salt also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |