Certificate of Analysis
| Product Name: | NLRP3-IN-NBC6 |
| Catalog Number: | M54573 |
| CAS Number: | 2068818-02-8 |
Physical and Chemical Properties
| Formula: | C18H16BCl3N2O2 |
| Molecular Weight: | 409.50 |
| Form: | Solid |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | NLRP3-IN-NBC6 is a potent and selective NLRP3 inflammatory vesicle inhibitor (IC50= 574 nM) that acts independently of Ca2+.NLRP3-IN-NBC6 inhibits Nigericin-induced inflammatory responses in THP-1 cells and Imiquimod-induced LPS-primed bone marrow-derived macrophages ( BMDMs) release of IL-1β. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |