Certificate of Analysis
| Product Name: | Napabucasin (BBI608) |
| Catalog Number: | M5807 |
| CAS Number: | 83280-65-3 |
Physical and Chemical Properties
| Formula: | C14H8O4 |
| Molecular Weight: | 240.21 |
| Solubility: | DMSO 4 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.86% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Napabucasin (BBI608) is a first-in-class, orally active inhibitor of Stat3 that blocks stem cell activity in cancer cells by targeting the signal transducer and activator of transcription 3 pathway. Napabucasin inhibits cell proliferation of U87MG tumor xenografts in mice. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |