Certificate of Analysis
| Product Name: | MS31 trihydrochloride |
| Catalog Number: | M31013 |
Physical and Chemical Properties
| Formula: | C20H30Cl3N3O2 |
| Molecular Weight: | 450.83 |
| Form: | Solid |
| Solubility: | DMSO 62.5 mg/mL (ultrasonic) |
| Storage: | 4°C, dry, sealed |
Analytical Data
| QC Standard: | ≥99.0% |
Product Information
| Description: | MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 trihydrochloride selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, and is not toxic to nontumorigenic cells. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |