Product Name: | Momelotinib sulfate |
Catalog Number: | M13852 |
CAS Number: | 1056636-06-6 |
Molecular Weight: | 610.62 |
Solubility: | DMSO 150 mg/mL; Water 90 mg/mL |
Storage: | 2-8°C, dry, sealed |
Chemical Structure: | ![]() |
QC Standard: | >99% |
H-NMR: | Consistent with structure |
Description: | Momelotinib sulfate (CYT387 sulfate salt) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, 10-fold selectivity versus JAK3 (IC50=155 nM). In addition, Momelotinib is an inhibitor of activin A receptor type I (ACVR1). It may be used in studies related to myelofibrosis. |
Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |