Certificate of Analysis
| Product Name: | MK-8033 hydrochloride |
| Catalog Number: | M28116 |
| CAS Number: | 1283000-43-0 |
Physical and Chemical Properties
| Formula: | C25H22ClN5O3S |
| Molecular Weight: | 507.99 |
| Form: | Solid |
| Solubility: | Water 7.14 mg/mL (ultrasonic); DMSO 5.88 mg/mL (ultrasonic) |
| Storage: | 4°C, dry, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | MK-8033 hydrochloride is an orally active ATP competitive c-Met/Ron dual inhibitor (IC50s: 1 nM (c-Met),7 nM (Ron)), with preferential binding to the activated kinase conformation. MK-8033 hydrochloride can be used in the research of cancers, such as breast and bladder cancers, non-small cell lung cancers (NSCLCs). |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |