Certificate of Analysis

 

Product Name: Grazoprevir potassium salt
Catalog Number: M27943
CAS Number: 1206524-86-8

Physical and Chemical Properties
Formula: C38H49KN6O9S
Molecular Weight: 804.99
Form: Solid
Solubility: DMSO ≥ 100 mg/mL
Storage: 4°C, dry, sealed
Chemical Structure: Grazoprevir potassium salt Structure
Analytical Data
QC Standard: ≥99.0%
H-NMR: Consistent with structure
Product Information
Description: Grazoprevir potassium salt (MK-5172 potassium salt) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively. Grazoprevir potassium salt inhibits SARS-CoV-2 3CLpro activity.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.