Certificate of Analysis
| Product Name: | Adavosertib (MK-1775) |
| Catalog Number: | M2143 |
| CAS Number: | 955365-80-7 |
Physical and Chemical Properties
| Formula: | C27H32N8O2 |
| Molecular Weight: | 500.61 |
| Solubility: | DMSO 90 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.89% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Adavosertib (AZD1775, MK-1775) is a small pyrazolacil derivative, an effective ATP competitive specific inhibitor of WEE1 kinase, with IC50 of 5.2 nM. It can inhibit G2 phase DNA damage test sites. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |