Certificate of Analysis


Product Name: Adavosertib (MK-1775)
Catalog Number: M2143
CAS Number: 955365-80-7

Physical and Chemical Properties
Formula: C27H32N8O2
Molecular Weight: 500.61
Solubility: DMSO 70 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Adavosertib (MK-1775) Structure
Analytical Data
QC Standard: 99.89%
H-NMR: Consistent with structure
Product Information
Description: Adavosertib (AZD1775, MK-1775) is a small pyrazolacil derivative, an effective ATP competitive specific inhibitor of WEE1 kinase, with IC50 of 5.2 nM. It can inhibit G2 phase DNA damage test sites.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.