Certificate of Analysis
| Product Name: | Methotrexate disodium |
| Catalog Number: | M13588 |
| CAS Number: | 7413-34-5 |
Physical and Chemical Properties
| Formula: | C20H20N8Na2O5 |
| Molecular Weight: | 498.4 |
| Solubility: | Water 50 mg/mL; DMSO 5 mg/mL (ultrasonic and warming and adjust pH to 5 with HCl and heat to 60°C) |
| Storage: | 2-8°C, protect from light, dry, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |