Certificate of Analysis
| Product Name: | PROTAC Mcl1 degrader-1 |
| Catalog Number: | M29314 |
| CAS Number: | 2163793-38-0 |
Physical and Chemical Properties
| Formula: | C45H45BrN6O8S |
| Molecular Weight: | 909.84 |
| Form: | Solid |
| Solubility: | DMSO 50 mg/mL (ultrasonic) |
| Storage: | -20°C, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC50 of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC50 of 0.54 μM. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |