Certificate of Analysis
| Product Name: | LT052 |
| Catalog Number: | M10849 |
| CAS Number: | 2543545-44-2 |
Physical and Chemical Properties
| Formula: | C22H19N5O4S |
| Molecular Weight: | 449.48 |
| Solubility: | DMSO 10 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >98.5% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | LT052 is a highly selective BET BD1 inhibitor with an IC50 of 87.7 nM. LT052 exhibits nanomolar BRD4 BD1 potency and 138-fold selectivity over BRD4 BD2 (IC50=12.130 μM). LT052 has anti-inflammatory activity and can be used for the research of acute gout arthritis. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |