Certificate of Analysis


Product Name: Selitrectinib (LOXO-195)
Catalog Number: M9107
CAS Number: 2097002-61-2

Physical and Chemical Properties
Formula: C20H21FN6O
Molecular Weight: 380.42
Solubility: DMSO ≥ 55 mg/mL (Need ultrasonic)
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Selitrectinib (LOXO-195) Structure
Analytical Data
QC Standard: 99.67%
H-NMR: Consistent with structure
Product Information
Description: Selitrectinib (LOXO-195) is a potent and selective, next-generation TRK inhibitor, with IC50 values of 0.6±0.1 nM, <2.5 nM for TRKA and TRKC, respectively.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.