Certificate of Analysis


Product Name: Larotrectinib (LOXO-101)
Catalog Number: M6151
CAS Number: 1223403-58-4

Physical and Chemical Properties
Formula: C21H22F2N6O2
Molecular Weight: 428.44
Solubility: DMSO 4.3 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Larotrectinib (LOXO-101) Structure
Analytical Data
QC Standard: 99.56%
H-NMR: Consistent with structure
Product Information
Description: Larotrectinib (LOXO-101) is a potent, ATP competitive TRK inhibitor with IC50s in low nanomolar range for inhibition of all TRK family members in binding and cellular assays, with 100x selectivity over other kinases, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.