Certificate of Analysis
| Product Name: | Larotrectinib (LOXO-101) |
| Catalog Number: | M6151 |
| CAS Number: | 1223403-58-4 |
Physical and Chemical Properties
| Formula: | C21H22F2N6O2 |
| Molecular Weight: | 428.44 |
| Solubility: | DMSO 4.3 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.56% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Larotrectinib (LOXO-101) is a potent, ATP competitive TRK inhibitor with IC50s in low nanomolar range for inhibition of all TRK family members in binding and cellular assays, with 100x selectivity over other kinases, with 2 to 20 nM cellular potency against the TRKA, TRKB, and TRKC kinases. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |