Certificate of Analysis
| Product Name: | Ribociclib succinate (LEE011 succinate) |
| Catalog Number: | M4889 |
| CAS Number: | 1374639-75-4 |
Physical and Chemical Properties
| Formula: | C27H36N8O5 |
| Molecular Weight: | 552.63 |
| Solubility: | DMSO ≥ 9 mg/mL; Water 3 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.57% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Ribociclib succinate (LEE011 succinate) is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |