Certificate of Analysis
| Product Name: | Ceritinib (LDK378) dihydrochloride |
| Catalog Number: | M6168 |
| CAS Number: | 1380575-43-8 |
Physical and Chemical Properties
| Formula: | C28H38Cl3N5O3S |
| Molecular Weight: | 631.06 |
| Solubility: | Water ≥ 100 mg/mL; DMSO ≥ 60 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.81% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Ceritinib dihydrochloride (LDK378 dihydrochloride) is potent inhibitor against ALK with IC50 of 0.2 nM, shows 40- and 35-fold selectivity against IGF-1R and InsR, respectively. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |