Certificate of Analysis

 

Product Name: Lapaquistat acetate
Catalog Number: M28996
CAS Number: 189060-13-7

Physical and Chemical Properties
Formula: C33H41ClN2O9
Molecular Weight: 645.14
Form: Solid
Solubility: DMSO 50 mg/mL (ultrasonic)
Storage: Powder -20°C
Chemical Structure: Lapaquistat acetate Structure
Analytical Data
QC Standard: ≥99.0%
H-NMR: Consistent with structure
Product Information
Description: Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene in the cholesterol biosynthesis pathway. Lapaquistat acetate is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage. Lapaquistat acetate is used for hypercholesterolemia and mevalonate kinase deficiency (MKD) research.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.