Certificate of Analysis
| Product Name: | KTX-582 |
| Catalog Number: | M54678 |
| CAS Number: | 2573298-13-0 |
Physical and Chemical Properties
| Formula: | C45H51F3N8O7 |
| Molecular Weight: | 872.93 |
| Form: | Solid |
| Solubility: | DMSO 100 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | KTX-582 is a potent IRAK4 degrader with a DC50 of 4 nM and 5 nM for IRAK4 and Ikaros, respectively.In addition, KTX-582 induces apoptosis in MYD88MT DLBCL cells and tumor regression in vivo in a lymphoma model. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |