Certificate of Analysis
| Product Name: | KP-457 |
| Catalog Number: | M58661 |
| CAS Number: | 1365803-52-6 |
Physical and Chemical Properties
| Formula: | C21H24N2O7S2 |
| Molecular Weight: | 480.55 |
| Form: | Solid |
| Solubility: | DMSO 95 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with IC50 of 11.1 nM (cell-free assay). KP-457 also cleaves various molecules such as GPIbα, GPV, and TNF-α. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |