Certificate of Analysis
| Product Name: | KB02-SLF |
| Catalog Number: | M29585 |
| CAS Number: | 2384184-40-9 |
Physical and Chemical Properties
| Formula: | C50H65ClN4O12 |
| Molecular Weight: | 949.52 |
| Form: | Solid |
| Solubility: | DMSO 100 mg/mL (ultrasonic) |
| Storage: | 4°C, protect from light, dry, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | KB02-SLF is a PROTAC-based nuclear FKBP12 degrader (molecular glue). KB02-SLF promotes nuclear FKBP12 degradation by covalently modifying DCAF16 (E3 ligase) and can improve the durability of protein degradation in biological systems. SLF binds ubiquitin E3 ligase ligand KB02 via a linker to form KB02-SLF. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |