Certificate of Analysis
| Product Name: | JQ-1 carboxylic acid |
| Catalog Number: | M6096 |
| CAS Number: | 202592-23-2 |
Physical and Chemical Properties
| Formula: | C19H17ClN4O2S |
| Molecular Weight: | 400.88 |
| Solubility: | DMSO 30 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 98.04% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | (+)-JQ1 carboxylic acid, the carboxylic acid form of (+)-JQ1, is a potent BET bromodomain inhibitor for downregulating PD-L1 expression on the surface of tumor cells. JQ-1 carboxylic acid can be used as a precursor to synthesize PROTACs, which targets BET bromodomains. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |