Certificate of Analysis
| Product Name: | Izeltabart |
| Catalog Number: | M55045 |
| CAS Number: | 2642078-60-0 |
Physical and Chemical Properties
| Form: | Liquid |
| Storage: | Store at ≤ -20°C. Aliquots should be stored at the same temperature after first use to avoid multiple freeze-thaws. |
Analytical Data
| QC Standard: | ≥95.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Izeltabart is a high-affinity humanized antibody targeting ADAM9. Izeltabart can be used as ADC Antibody for site-specific conjugation with Maytansinoid-based DM21-C to synthesize IMGC936, an Antibody-drug Conjugate with strong anti-cancer activity. IMGC936 exhibits cytotoxicity against ADAM9-positive human tumor cell lines and potent antitumor activity in xenograft tumor models. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |