Product Name:	IDH889
Catalog Number:	M11277
CAS Number:	1429179-07-6

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Physical and Chemical Properties

Formula:	C23H25FN6O2
Molecular Weight:	436.48
Solubility:	DMSO ≥ 100 mg/mL
Storage:	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure:

Analytical Data

QC Standard:	>98%
H-NMR:	Consistent with structure

Product Information

Description:	IDH889 is an orally available, brain permeable, allosteric and mutation-specific inhibitor of isocitrate dehydrogenase (IDH1). IDH889 showed high selectivity against IDH1R132 * mutant, with IC50 values of 0.02 μM, 0.072 μM and 1.38 μM against IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 showed high inhibition of intracellular 2-Hg level with IC50 value of 0.014 μM.
Stability and Solubility Advice:	Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.

AbMole BioScience

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