Certificate of Analysis

 

Product Name: GKT136901 hydrochloride 
Catalog Number: M28052
CAS Number: 1254507-01-1

Physical and Chemical Properties
Formula: C19H16Cl2N4O2
Molecular Weight: 403.26
Form: Solid
Solubility: DMSO 62.5 mg/mL (ultrasonic); Water 4 mg/mL (ultrasonic and warming and heat to 60°C)
Storage: 4°C, dry, sealed
Chemical Structure: GKT136901 hydrochloride  Structure
Analytical Data
QC Standard: ≥99.0%
H-NMR: Consistent with structure
Product Information
Description: GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.