Certificate of Analysis
| Product Name: | Cobimetinib (GDC-0973) |
| Catalog Number: | M3626 |
| CAS Number: | 934660-93-2 |
Physical and Chemical Properties
| Formula: | C21H21F3IN3O2 |
| Molecular Weight: | 531.31 |
| Solubility: | DMSO 30 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 100% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Cobimetinib (GDC-0973, RG7420) is an effective, selective, oral MEK1 inhibitor with an IC50 of 4.2 nM against MEK1. In addition, Cobimetinib is an inhibitor of Akt. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |