Product Name: | GA-017 |
Catalog Number: | M21084 |
CAS Number: | 2351906-74-4 |
Formula: | C18H21N3O4 |
Molecular Weight: | 343.38 |
Form: | Solid |
Solubility: | DMSO : 20.83 mg/mL |
Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Chemical Structure: |
QC Standard: | >98% |
H-NMR: | Consistent with structure |
Description: | GA-017 is a potent and selective inhibitor of LATS1 and LATS2 (large tumor suppressor kinase 1/2) with IC50 values of 4.10 and 3.92 nM, respectively.GA-017 is a cell proliferation activator.GA-017 promotes YAP/TAZ activation and nuclear translocation.GA-017 promotes cell growth in 3D culture conditions.GA-017 Enhances the formation of mouse intestinal organoid isolates. |
Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |