Certificate of Analysis
| Product Name: | Fedratinib hydrochloride hydrate |
| Catalog Number: | M28279 |
| CAS Number: | 1374744-69-0 |
Physical and Chemical Properties
| Formula: | C27H40Cl2N6O4S |
| Molecular Weight: | 615.62 |
| Form: | Solid |
| Solubility: | DMSO 100 mg/mL (ultrasonic); Water 100 mg/mL (ultrasonic) |
| Storage: | 4°C, dry, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Fedratinib hydrochloride hydrate (TG-101348 hydrochloride hydrate) is a potent, selective, ATP-competitive and orally active JAK2 inhibitor with IC50s of 3 nM for both JAK2 and JAK2V617F kinase. Fedratinib hydrochloride hydrate shows 35- and 334-fold selectivity over JAK1 and JAK3, respectively. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |