Certificate of Analysis
| Product Name: | E6446 dihydrochloride |
| Catalog Number: | M9289 |
| CAS Number: | 1345675-25-3 |
Physical and Chemical Properties
| Formula: | C27H37Cl2N3O3 |
| Molecular Weight: | 522.51 |
| Solubility: | DMSO 5.2 mg/mL (Need ultrasonic and warming) |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | E6446 dihydrochloride is a potent and orally acitve antagonist of TLR7 and TLR9. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |