Certificate of Analysis


Product Name: Dolutegravir
Catalog Number: M3484
CAS Number: 1051375-16-6

Physical and Chemical Properties
Formula: C20H19F2N3O5
Molecular Weight: 419.38
Solubility: DMSO 10 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Dolutegravir Structure
Analytical Data
QC Standard: 99.68%
H-NMR: Consistent with structure
Product Information
Description: Dolutegravir (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H.
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.