Certificate of Analysis

 

Product Name: CYC116
Catalog Number: M1694
CAS Number: 693228-63-6

Physical and Chemical Properties
Formula: C18H20N6OS
Molecular Weight: 368.46
Solubility: DMSO 12 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: CYC116 Structure
Analytical Data
QC Standard: >99%
H-NMR: Consistent with structure
Product Information
Description: CYC116 is a potent, small molecule inhibitor of Aurora A, B and C with IC50 value of 44, 19 and 65 nM respectively. CYC-116 also inhibits VEGFR2, Src, Lck AND FLT3 with with Kis of 44, 82, 280, 44 nM, respectively. CYC-116 may have broad-spectrum antitumor activity.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.