Certificate of Analysis
| Product Name: | CUR5g |
| Catalog Number: | M45399 |
| CAS Number: | 1370032-20-4 |
Physical and Chemical Properties
| Formula: | C22H20N2O2 |
| Molecular Weight: | 344.41 |
| Form: | Solid |
| Solubility: | DMSO 41.67 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | CUR5g is a potent autophagy inhibitor that selectively inhibits autophagosome degradation in cancer cells by blocking autophagosome-lysosome fusion. CUR5g also prevents STX17 from being recruited to autophagosomes through a UVRAG-dependent mechanism, resulting in the inability of autophagosomes to fuse with lysosomes. In addition, CUR5g enhances the in vitro and in vivo anticancer effects of cisplatin in A549 cells. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |