Certificate of Analysis

 

Product Name: Capmatinib hydrochloride
Catalog Number: M40733
CAS Number: 1029714-89-3

Physical and Chemical Properties
Formula: C23H18ClFN6O
Molecular Weight: 448.89
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Capmatinib hydrochloride Structure
Analytical Data
QC Standard: >99.0%
H-NMR: Consistent with structure
Product Information
Description: Capmatinib hydrochloride is a potent, orally active, selective, ATP-competitive c-Met kinase inhibitor that inhibits the phosphorylation of c-MET and downstream effector proteins of the c-MET pathway, with an IC50 value of 0.13 nM. In addition, Capmatinib hydrochloride In addition, Capmatinib hydrochloride can inhibit the proliferation and migration of c-Met-dependent tumor cells, and can effectively induce apoptosis (apoptosis), with anti-tumor activity.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.