Certificate of Analysis
| Product Name: | Deucravacitinib (BMS-986165) |
| Catalog Number: | M4138 |
| CAS Number: | 1609392-27-9 |
Physical and Chemical Properties
| Formula: | C20H19D3N8O3 |
| Molecular Weight: | 425.46 |
| Solubility: | DMSO ≥ 30 mg/mL |
| Storage: | -20°C |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99.5% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Deucravacitinib (BMS-986165) is a first-in-class, selective, orally bioavailable inhibitor of TYK2 transitions.Deucravacitinib selectively binds the TYK2 pseudokinase (JH2) structural domain with an IC50 of 1.0 nM and a Ki value of 0.02 nM. Deucravacitinib (BMS-986165) blocks receptor-mediated Tyk2 activation by stably regulating the JH2 structural domain. deucravacitinib also inhibits the IL-12/23 and type I IFN pathways. deucravacitinib may be used in psoriasis research. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |