Product Name: | BMH-21 |
Catalog Number: | M3892 |
CAS Number: | 896705-16-1 |
Formula: | C21H20N4O2 |
Molecular Weight: | 360.41 |
Solubility: | DMSO |
Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Chemical Structure: |
QC Standard: | >98% |
H-NMR: | Consistent with structure |
Description: | BMH-21 is a first-in-class DNA intercalator that binds to high-frequency GC-rich sequences in ribosomal DNA genes and can effectively and rapidly inhibit the transcription of RNA polymerase I (Pol I), leading to degradation of the Pol I catalytic subunit RPA194 and non-phosphorylation of histone H2AX. H2AX is not phosphorylated.BMH-21 has broad and potent antitumor activity in NCI60 cancer cell line and inhibits tumor growth in vivo. |
Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |