Certificate of Analysis
| Product Name: | BIIB129 |
| Catalog Number: | M58129 |
| CAS Number: | 2770960-52-4 |
Physical and Chemical Properties
| Formula: | C19H22N6O2 |
| Molecular Weight: | 366.42 |
| Solubility: | DMSO 80 mg/mL |
| Storage: | 4°C, sealed |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | BIIB129 is a covalent, selective inhibitor of Bruton's tyrosine kinase (BTK) capable of penetrating the blood-brain barrier. BIIB129 inhibits the activity of BTK by covalently binding to Cys481 in BTK, thereby affecting the function of B cells and myeloid cells. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |