Product Name: | BI-9627 hydrochloride |
Catalog Number: | M28388 |
CAS Number: | 1422252-46-7 |
Formula: | C16H20ClF3N4O2 |
Molecular Weight: | 392.8 |
Form: | Solid |
Solubility: | DMSO 100 mg/mL (ultrasonic); Water 4.17 mg/mL (ultrasonic and warming and heat to 60°C) |
Storage: | 4°C, dry, sealed |
Chemical Structure: |
QC Standard: | ≥99.0% |
H-NMR: | Consistent with structure |
Description: | BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury. |
Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |