Certificate of Analysis

 

Product Name: Begacestat
Catalog Number: M3619
CAS Number: 769169-27-9

Physical and Chemical Properties
Formula: C9H8ClF6NO3S2
Molecular Weight: 391.74
Solubility: DMSO 40 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Begacestat Structure
Analytical Data
QC Standard: >99%
H-NMR: Consistent with structure
Product Information
Description: Begacestat selectively inhibits cleavage of amyloid precursor protein (APP) over Notch. Lowers levels of Aβ42 and Aβ40 (EC50 values are 12.4 and 14.8 nM respectively in cells expressing human recombinant APP).
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.