Certificate of Analysis
| Product Name: | AZ1495 |
| Catalog Number: | M21784 |
| CAS Number: | 2196204-23-4 |
Physical and Chemical Properties
| Formula: | C21H31N5O2 |
| Molecular Weight: | 385.5 |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | ≥99% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | AZ1495 is a weak base and orally active, potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with a Kd value of 0.0007 μM.AZ1495 has good physicochemical and kinase selectivity for IRAK4 and IRAK1, with IC50 values of 0.005 μM and 0.023 μM, respectively.AZ1495 is used in studies of diffuse large B-cell lymphoma (DLBCL). |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |