Certificate of Analysis
| Product Name: | AX-024 hydrochloride |
| Catalog Number: | M9298 |
| CAS Number: | 1704801-24-0 |
Physical and Chemical Properties
| Formula: | C21H23ClFNO2 |
| Molecular Weight: | 375.86 |
| Solubility: | DMSO 30 mg/mL; Water 8 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | 99.11% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Ax-024 Hydrochloride is orally available, the first tCR-NCK interaction inhibitor that selectively inhibits TCR-induced T cell activation with an IC50 value of 1 nM. Ax-024 Hydrochloride regulates cellular signaling by targeting the SH3 domain. Ax-024 Hydrochloride has the characteristics of low toxicity, high efficiency and high selectivity. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |