Certificate of Analysis


Product Name: Spebrutinib (AVL-292)
Catalog Number: M2113
CAS Number: 1202757-89-8

Physical and Chemical Properties
Formula: C22H22FN5O3
Molecular Weight: 423.44
Solubility: DMSO 60 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Spebrutinib (AVL-292) Structure
Analytical Data
QC Standard: >99%
H-NMR: Consistent with structure
Product Information
Description: Spebrutinib (AVL-292) is an oral, potent and selective small molecule covalent inhibitor of Btk (IC50 < 0.5 nM).
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.