Certificate of Analysis
| Product Name: | Aurantiamide |
| Catalog Number: | M16118 |
| CAS Number: | 58115-31-4 |
Physical and Chemical Properties
| Formula: | C25H26N2O3 |
| Molecular Weight: | 402.49 |
| Solubility: | DMSO 42 mg/mL |
| Storage: | -20°C, protect from light |
| Chemical Structure: |  |
Product Information
| Description: | Aurantiamide is a non-covalent, orally active, blood-brain-permeable GRPR selective antagonist with anti-inflammatory and neuroprotective effects. Aurantiamide reduces inflammation and oxidative stress in renal tissue by inhibiting GRPR-mediated renal necrosis pathways (such as RIPK3/MLKL signaling) and NF-κB inflammatory pathways, exerting anti-acute kidney injury and endothelial function activities. Aurantiamide also inhibits the M1 polarization of microglia and inhibits NLRP3 activation. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |