Certificate of Analysis
| Product Name: | ASP2453 |
| Catalog Number: | M21220 |
| CAS Number: | 2241719-73-1 |
Physical and Chemical Properties
| Formula: | C40H48F3N7O4 |
| Molecular Weight: | 747.85 |
| Solubility: | DMSO ≥ 200 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >97% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C. ASP2453 inhibits Son of Sevenless (SOS)-mediated interactions between KRAS G12C and Raf with an IC50 value of 40 nM. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |