Certificate of Analysis
| Product Name: | Apostatin-1 |
| Catalog Number: | M21568 |
| CAS Number: | 2559703-06-7 |
Physical and Chemical Properties
| Formula: | C19H27N3OS |
| Molecular Weight: | 345.51 |
| Solubility: | DMSO ≥ 40 mg/mL |
| Storage: |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Chemical Structure: |  |
Analytical Data
| QC Standard: | >99.0% |
| H-NMR: | Consistent with structure |
Product Information
| Description: | Apostatin-1 (Apt-1) is a new type of TRADD inhibitor. Apostatin 1 can bind to TRADD-N (KD=2.17 μM), and destroy the binding of Apostatin 1 to TRADD-C and TRAF2. Apostatin-1 regulates ubiquitination of RIPK1 and beclin 1. By activating autophagy in cells accumulated by mutated tau, α-synuclein or huntingtin, Apostatin 1 blocked apoptosis and restored homeostasis. |
| Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |